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A quantitative AOP of mitochondrial toxicity based on data from three cell lines

Toxicology in Vitro, Volume 81 (2022); DOI: 10.1016/j.tiv.2022.105345

A Novel UPLC-MS Metabolomic Analysis-Based Strategy to Monitor the Course and Extent of iPSC Differentiation to Hepatocytes

Journal of Proteome Research (2022); DOI: 10.1021/acs.jproteome.1c00779

Specific attenuation of purinergic signaling during bortezomib-induced peripheral neuropathy

bioRxiv (2022); DOI: 10.1101/2022.02.17.479688

Zebrafish embryo neonicotinoid developmental neurotoxicity in the FET test and behavioral assays

ALTEX (2022); DOI: 10.14573/altex.2111021

Acute effects of the imidacloprid metabolite desnitro-imidacloprid on human nACh receptors relevant for neuronal signaling

Archives of Toxicology volume 95, pages 3695–3716 (2021); DOI: 10.1007/s00204-021-03168-z

Neurotoxic effects in zebrafish embryos by valproic acid and nine of its analogues: the fish-mouse connection?

Archives of Toxicology volume 95, pages 641–657 (2021); DOI: 10.1007/s00204-020-02928-7

Neurodevelopmental toxicity assessment of flame retardants using a human DNT in vitro testing battery

Cell Biology and Toxicology (2021);DOI: 10.1007/s10565-021-09603-2

Metabolically Improved Stem Cell Derived Hepatocyte-Like Cells Support HBV Life Cycle and Are a Promising Tool for HBV Studies and Antiviral Drug Screenings

Biomedecines (2022); DOI: 10.3390/biomedicines10020268

Application of high-throughput transcriptomics for mechanism-based biological read-across of short-chain carboxylic acid analogues of valproic acid

ALTEX, 39 (2);DOI: 10.14573/altex.2107261

HiPSC-Derived Hepatocyte-like Cells Can Be Used as a Model for Transcriptomics-Based Study of Chemical Toxicity

Toxics 2022, 10(1); DOI: 10.3390/toxics10010001

Ten simple rules for creating reusable pathway models for computational analysis and visualization

PLoS Comput Biol (2021); DOI: 10.1371/journal.pcbi.1009226

The human hepatocyte TXG-MAPr: gene co-expression network modules to support mechanism-based risk assessment

Archives of Toxicology volume 96, pages259–285 (2022); DOI: 10.1007/s00204-021-03160-7

The hepatocyte export carrier inhibition assay improves the separation of hepatotoxic from non-hepatotoxic compounds

Chemico-Biological Interactions, Volume 351, 5 January 2022, 109728; DOI: 10.1016/j.cbi.2021.109728

ELIXIR and Toxicology: a community in development

F1000Research 2021, 10(ELIXIR):1129; DOI: 10.12688/f1000research.74502.1

Integrate mechanistic evidence from new approach methodologies (NAMs) into a read-across assessment to characterise trends in shared mode of action

Toxicology in Vitro, Volume 79, March 2022, 105269; DOI: 10.1016/j.tiv.2021.105269

Specificity of time- and dose-dependent morphological endpoints in the fish embryo acute toxicity (FET) test for substances with diverse modes of action: the search for a “fingerprint”

Environmental Science and Pollution Research volume 29, pages 16176–16192 (2022); DOI: 10.1007/s11356-021-16354-4

Mapping the cellular response to electron transport chain inhibitors reveals selective signaling networks triggered by mitochondrial perturbation

Archives of Toxicology volume 96, pages 259–285 (2022); DOI: 10.1007/s00204-021-03160-7

Transcriptomic Cross-Species Analysis of Chronic Liver Disease Reveals Consistent Regulation Between Humans and Mice

Hepatology Communications (2021); DOI: 10.1002/hep4.1797

A fully defined matrix to support a pluripotent stem cell derived multi-cell-liver steatohepatitis and fibrosis model

Biomaterials Volume 276, September 2021, 121006; DOI: 10.1016/j.biomaterials.2021.121006

Fluorescent tagging of endogenous Heme oxygenase-1 in human induced pluripotent stem cells for high content imaging of oxidative stress in various differentiated lineages

Archives of Toxicology volume 95, pages 3285–3302 (2021); DOI: 10.1007/s00204-021-03127-8

Towards an advanced testing strategy for genotoxicity using image-based 2D and 3D HepG2 DNA damage response fluorescent protein reporters

Mutagenesis, geab031 (2021); DOI: 10.1093/mutage/geab031

Identifying novel transcript biomarkers for hepatocellular carcinoma (HCC) using RNA-Seq datasets and machine learning

BMC Cancer 21, 962 (2021); DOI: 10.1186/s12885-021-08704-9

Factors that Influence the Quality of Metabolomics Data in in Vitro Cell Toxicity Studies: A Systematic Survey

Research Square (2021); DOI: 10.21203/

New approach methods supporting read-across: Two neurotoxicity AOP-based IATA case studies

ALTEX - Alternatives to animal experimentation, 38(4), pp. 615–635 ; DOI: 10.14573/altex.2103051

The in vitro assessment of the toxicity of volatile, oxidisable, redox-cycling compounds: phenols as an example

Archives of Toxicology volume 95, pages2109–2121 (2021); DOI: 10.1007/s00204-021-03036-w

Flame: an open source framework for model development, hosting, and usage in production environments

Journal of Cheminformatics (2021); DOI : 10.21203/

Generation and characterization of iPSC-derived renal proximal tubule-like cells with extended stability

Cell Biology and Toxicology (2021); DOI: 10.1038/s41598-021-89550-4

Neurodevelopmental toxicity assessment of flame retardants using a human DNT in vitro testing battery

Cell Biology and Toxicology (2021) ; DOI: 10.1007/s10565-021-09603-2

Stimulation of de novo glutathione synthesis by nitrofurantoin for enhanced resilience of hepatocytes

Cell Biology and Toxicology (2021) ; DOI: 10.1007/s10565-021-09610-3

Directed differentiation of human induced pluripotent stem cells to hepatic stellate cells

Nature Protocols volume 16, pages 2542–2563 (2021); DOI : 10.1038/s41596-021-00509-1

Integration of temporal single cell cellular stress response activity with logic-ODE modeling reveals activation of ATF4-CHOP axis as a critical predictor of drug-induced liver injury

Biochemical Pharmacology Volume 190, 114591 (August 2021); DOI: 10.1016/j.bcp.2021.114591

A human stem cell-derived test system for agents modifying neuronal N-methyl-D-aspartate-type glutamate receptor Ca2+-signalling

Arch Toxicol 95, 1703–1722 (2021); DOI: 10.1007/s00204-021-03024-0

Physiologically Relevant Estrogen Receptor Alpha Pathway Reporters for Single-Cell Imaging-Based Carcinogenic Hazard Assessment of Estrogenic Compounds

Toxicological Sciences, Volume 181, Issue 2, June 2021, Pages 187–198; DOI: 10.1093/toxsci/kfab037

Systematic transcriptome-based comparison of cellular adaptive stress response activation networks in hepatic stem cell-derived progeny and primary human hepatocytes

Toxicology in Vitro, Volume 73 (June 2021), Article 105107; doi: 10.1016/j.tiv.2021.105107

Functional alterations by a subgroup of neonicotinoid pesticides in human dopaminergic neurons

Arch Toxicol 95, 2081-2107 (2021); DOI: 10.1007/s00204-021-03031-1

Effective exposure of chemicals in in vitro cell systems: A review of chemical distribution models

Toxicology Letters; doi: 10.1016/j.tiv.2021.105133

A quantitative in vivo assay for craniofacial developmental toxicity of histone deacetylases

Toxicology Letters; doi: 10.1016/j.toxlet.2021.02.005

Combining In Vivo Data with In Silico Predictions for Modeling Hepatic Steatosis by Using Stratified Bagging and Conformal Prediction

Chem. Res. Toxicol. 2020, DOI: 10.1021/acs.chemrestox.0c00511

Adverse effects in the fish embryo acute toxicity (FET) test: a catalogue of unspecific morphological changes versus more specific effects in zebrafish (Danio rerio) embryos

Environ Sci Eur 32, 122 (2020).

Setting the stage for next-generation risk assessment with non-animal approaches: the EU-ToxRisk project experience

Arch Toxicol 94, 3581–3592 (2020). DOI 10.1007/s00204-020-02866-4

A read-across study on diketones.

The Toxicologist Supplement to Toxicological Sciences, 168 (1), 243

ATF6 Is a Critical Determinant of CHOP Dynamics during the Unfolded Protein Response

iScience, Vol 23, Issue 2, DOI 10.1016/j.isci.2020.100860

Inflammation-associated suppression of metabolic gene networks in acute and chronic liver disease .

Arch Toxicol, Vol 94, Pages 205-217, DOI 10.1007/s00204-019-02630-3

The exposome – a new approach for risk assessment

ALTEX, Vol 37, Issue 1, Pages 3-23, DOI 10.14573/altex.2001051

Evaluation of the global performance of eight in silico skin sensitization models using human data

ALTEX (2020), DOI 10.14573/altex.1911261

Using Machine Learning Methods and Structural Alerts for Prediction of Mitochondrial Toxicity

Molecular Informatics, Vol 39, Issue 5, DOI 10.1002/minf.202000005

Identification of mitochondrial toxicants by combined in silico and in vitro studies – A structure-based view on the adverse outcome pathway

Computational Toxicology, Vol 14, Pages 100-123, DOI 10.1016/j.comtox.2020.100123

Development of a generic zebrafish embryo PBPK model and application to the developmental toxicity assessment of valproic acid analogs

Reproductive Toxicology, Vol 93, Pages 219-229, DOI 10.1016/j.reprotox.2020.02.010

Investigation of Nrf2, AhR and ATF4 activation in toxicogenomic databases

Frontiers in Genetics (2018), DOI 10.3389/fgene.2018.00429

sAOP: linking chemical stressors to adverse outcome pathway networks

Bioinformatics, Vol 35, Issue 24, Pages 5391-5392, DOI10.1093/bioinformatics/btz570

The use of systems biology in chemical risk assessment.

Current opinion in toxicology, Vol 15, Pages 48-54,

Time- and space-resolved quantification of plasma membrane sialylation for measurements of cell function and neurotoxicity

Arch Toxicol, Vol 94, Issue 2, Pages 449-467, DOI 10.1007/s00204-019-02642-z

Incorporation of stem cell-derived astrocytes into neuronal organoids to allow neuro-glial interactions in toxicological studies

ALTEX, Vol 37, Issue 3, DOI 10.14573/altex.1911111

Design and evaluation of bi-functional iron chelators for protection of dopaminergic neurons from toxicants

Arch Toxicol; 2020

Human Induced Pluripotent Stem Cell-Derived 3D-Neurospheres Are Suitable for Neurotoxicity Screening

Cells; Vol 9, Issue 5, Page 1122, DOI 10.3390/cells9051122

The EU-ToxRisk method documentation, data processing and chemical testing pipeline for the regulatory use of new approach methods

Arch. Toxicol; Vol 94, Pages 2435–2461, DOI 10.1007/s00204-020-02802-6

Harnessing the power of novel animal-free test methods for the development of COVID-19 drugs and vaccines

Arch. Toxicol; Vol 94, Issue 6, Pages 2263-2272, DOI 10.1007/s00204-020-02787-2

Internationalization of read-across as a validated new approach method (NAM) for regulatory toxicology

ALTEX, 2020, DOI 10.14573/altex.1912181

Biology-inspired Microphysiological systems to advance patient benefit and animal welfare in drug development

ALTEX, Vol 37, Issue 3, DOI 10.14573/altex.2001241

Determination of benchmark concentrations and their statistical uncertainty for cytotoxicity test data and functional in vitro assays

ALTEX, Vol 37, Issue 1, Pages 155-163, DOI 10.14573/altex.1912021

Multiparametric assessment of mitochondrial respiratory inhibition in HepG2 and RPTEC/TERT1 cells using a panel of mitochondrial targeting agrochemicals

Arch. Toxicol, Vol 94, Issue 8, Pages 1-23, DOI 10.1007/s00204-020-02792-5

Automated integration of structural, biological and metabolic similarities to sustain read-across

ALTEX, Vol 37, Issue 3, DOI 10.14573/altex.2002281

Road map for development of stem cell-based alternative test methods.

Trends in Molecular Medicine, Volume 25, Issue 6, June 2019, Pages 470-481

Structure learning of Bayesian networks involving cyclic structures

HAL Archives

Environ Int. 2019 Oct;131:105060. doi: 10.1016/j.envint.2019.105060

Towards grouping concepts based on new approach methodologies in chemical hazard assessment: the read-across approach of the EU-ToxRisk project

Arch Toxicol (2019) 93: 3643.

Analysis of Time-Series Gene Expression Data to Explore Mechanisms of Chemical-Induced Hepatic Steatosis Toxicity

Front. Genet. 9:396. doi: 10.3389/fgene.2018.00396

Optimizing drug discovery by Investigative Toxicology: Current and future trends

ALTEX - Alternatives to animal experimentation, 36(2), pp. 289-313. doi: 10.14573/altex.1808181.

A systematic analysis of Nrf2 pathway activation dynamics during repeated xenobiotic exposure

Arch Toxicol (2019) 93: 435.

Environ Int. 2018 Nov;120:544-562. doi: 10.1016/j.envint.2018.07.037

Regulatory Acceptance of Read-Across

ALTEX - Alternatives to animal experimentation, 35(3), pp. 413-419. doi: 10.14573/altex.1805081

Characterisation of the Nrf2 transcriptional network and its response to chemical insult in primary human hepatocytes: implications for prediction of drug-induced liver injury

Arch Toxicol (2019) 93: 385.

Computational Toxicology: Risk Assessment for Chemicals_Computational Toxicology and Reach

Chapter in Computational Toxicology: Risk Assessment for Chemicals_Computational Toxicology and Reach, ISBN: 978-1-119-28256-3

Arch Toxicol. 2018 Dec;92(12):3517-3533. doi: 10.1007/s00204-018-2352-3.

Prevention of neuronal apoptosis by astrocytes through thiol-mediated stress response modulation and accelerated recovery from proteotoxic stress

Cell Death Differ 25, 2101–2117 (2018) doi:10.1038/s41418-018-0229-x

Toxicity, recovery, and resilience in a 3D dopaminergic neuronal in vitro model exposed to rotenone

Arch Toxicol (2018) 92: 2587.

Essential Components of Methods Papers

ALTEX - Alternatives to animal experimentation, 35(3), pp. 429-432. doi: 10.14573/altex.1807031

Machine Learning of Toxicological Big Data Enables Read-Across Structure Activity Relationships (RASAR) Outperforming Animal Test Reproducibility

Toxicological Sciences, Volume 165, Issue 1, September 2018, Pages 198–212,

NPJ Syst Biol Appl. 2018 Jun 11;4:23. doi: 10.1038/s41540-018-0058-z

Advanced Good Cell Culture Practice for Human Primary, Stem Cell-Derived and Organoid Models as well as Microphysiological Systems

ALTEX - Alternatives to animal experimentation, 35(3), pp. 353-378. doi: 10.14573/altex.1710081.

The BioStudies database—one stop shop for all data supporting a life sciences study

Nucleic Acids Research, Volume 46, Issue D1, 4 January 2018, Pages D1266–D1270,

Spatio-temporal visualization of the distribution of acetaminophen as well as its metabolites and adducts in mouse livers by MALDI MSI

Arch Toxicol (2018) 92: 2963.

An adverse outcome pathway for parkinsonian motor deficits associated with mitochondrial complex I inhibition

Arch Toxicol (2018) 92: 41.

Pharm Res. 2018 Dec 27;36(2):28. doi: 10.1007/s11095-018-2561-8.

Application of three approaches for quantitative AOP development to renal toxicity

Computational Toxicology. Volume 11, August 2019, Pages 1-13

Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations

Arch Toxicol (2019) 93: 1609.

Arch Toxicol (2019) 93: 1585.

Bile Microinfarcts in Cholestasis Are Initiated by Rupture of the Apical Hepatocyte Membrane and Cause Shunting of Bile to Sinusoidal Blood.

Hepatology, 69: 666-683. doi:10.1002/hep.30213

Paradigm shift in safety assessment using new approach methods: The EU-ToxRisk strategy

Current Opinion in Toxicology, Volume 15, June 2019, Pages 33-39

Chemical Concentrations in Cell Culture Compartments (C5) – Concentration Definitions

ALTEX - Alternatives to animal experimentation, 36(1), pp. 154-160. doi: 10.14573/altex.1901031.

Methods Mol Biol. 2019;1981:187-202. doi: 10.1007/978-1-4939-9420-5_13.

Integrating in silico models and read-across methods for predicting toxicity of chemicals: A step-wise strategy

Environment International. Volume 131, October 2019, 105060

SUIKER: Quantification of antigens in cell organelles, neurites and cellular sub-structures by imaging

ALTEX - Alternatives to animal experimentation, 36(3), pp. 518-520. doi: 10.14573/altex.1906251.

Finding synergies for the 3Rs – Repeated Dose Toxicity testing: Report from an EPAA Partners' Forum

Regulatory Toxicology and Pharmacology, Volume 108, November 2019, 104470

Trends Mol Med. 2019 Jun;25(6):470-481. doi: 10.1016/j.molmed.2019.04.003.

Autologous induced pluripotent stem cell-derived four-organ-chip

Future Science OA, Vol. 5, No. 8. 2019. 10.2144/fsoa-2019-0065

Predicting toxicity of chemicals: software beats animal testing

EFSA Journal. Volume 17, Issue S1. 2019. 10.2903/j.efsa.2019.e170710

High-throughput confocal imaging of differentiated 3D liver-like spheroid cellular stress response reporters for identification of drug-induced liver injury liability

Arch Toxicol. 2019 Oct;93(10):2895-2911. doi: 10.1007/s00204-019-02552-0

Template for the Description of Cell-Based Toxicological Test Methods to Allow Evaluation and Regulatory Use of the Data

ALTEX - Alternatives to animal experimentation, 36(4), pp. 682-699. doi: 10.14573/altex.1909271.

Development of a neural rosette formation assay (RoFA) to identify neurodevelopmental toxicants and to characterize their transcriptome disturbances

Arch Toxicol (2019). pp 1–21. 10.1007/s00204-019-02612-5

Statement on advancing the assessment of chemical mixtures and their risks for human health and the environment

Volume 134, January 2020, 105267. 10.1016/j.envint.2019.105267

Introducing WikiPathways as a Data-Source to Support Adverse Outcome Pathways for Regulatory Risk Assessment of Chemicals and Nanomaterials

Front. Genet., 21 December 2018, doi: 10.3389/fgene.2018.00661

VIVD: Virtual in vitro distribution model for the mechanistic prediction of intracellular concentrations of chemicals in in vitro toxicity assays

Toxicology in Vitro, December 2018,DOI:10.1016/j.tiv.2018.12.017

Persistence of Epigenomic Effects After Recovery From Repeated Treatment With Two Nephrocarcinogens.

Front Genet. 2018 Dec 3;9:558. doi: 10.3389/fgene.2018.00558. eCollection 2018.

A new semi-automated workflow for chemical data retrieval and quality checking for modeling applications

Journal of Cheminformatics 201810:60,

Major changes of cell function and toxicant sensitivity in cultured cells undergoing mild, quasi-natural genetic drift

Arch Toxicol. 2018 Oct 8, DOI: 10.1007/s00204-018-2326-5

Development of an Infrastructure for the Prediction of Biological Endpoints in Industrial Environments. Lessons Learned at the eTOX Project

Front. Pharmacol., 11 October 2018, DOI: 10.3389/fphar.2018.01147

Relevance of the incubation period in cytotoxicity testing with primary human hepatocytes

Arch Toxicol. 2018 Oct 13, DOI: 10.1007/s00204-018-2302-0

QSAR Modeling of ToxCast Assays Relevant to the Molecular Initiating Events of AOPs Leading to Hepatic Steatosis

J. Chem. Inf. Model. 58, 8, 1501-1517; DOI: 10.1021/acs.jcim.8b00297

Limonciel, A., Ates, G., Carta, G. et al. Arch Toxicol (2018).

Generation of Hepatic Stellate Cells from Human Pluripotent Stem Cells Enables In Vitro Modeling of Liver Fibrosis

Cell Stem Cell (2018),

Comparing the performance of meta-classifiers-a case study on selected imbalanced data sets relevant for prediction of liver toxicity.

J Comput Aided Mol Des. 2018 May;32(5):583-590. doi: 10.1007/s10822-018-0116-z. Epub 2018 Apr 6. PMID: 29626291 [PubMed - in process] Free PMC Article

Insights into the Structure, Function, and Ligand Discovery of the Large Neutral Amino Acid Transporter 1, LAT1.

Int J Mol Sci. 2018 Apr 24;19(5). pii: E1278. doi: 10.3390/ijms19051278. Review. PMID: 29695141 [PubMed - in process] Free PMC Article

Predicting drug resistance related to ABC transporters using unsupervised Consensus Self-Organizing Maps.

Sci Rep. 2018 May 1;8(1):6803. doi: 10.1038/s41598-018-25235-9. PMID: 29717183 [PubMed - in process] Free Article

Human Environmental Disease Network: A computational model to assess toxicology of contaminants.

ALTEX. 2017;34(2):289-300. doi: 10.14573/altex.1607201. Epub 2016 Oct 21. PMID: 27768803 [PubMed - indexed for MEDLINE]

A systems biology approach to predictive developmental neurotoxicity of a larvicide used in the prevention of Zika virus transmission.

Toxicol Appl Pharmacol. 2018 Feb 21. pii: S0041-008X(18)30060-7. doi: 10.1016/j.taap.2018.02.014. [Epub ahead of print] PMID: 29476864 [PubMed - as supplied by publisher]

DTNI: a novel toxicogenomics data analysis tool for identifying the molecular mechanisms underlying the adverse effects of toxic compounds.

Arch Toxicol. 2017 Jun;91(6):2343-2352. doi: 10.1007/s00204-016-1922-5. Epub 2016 Dec 28. PMID: 28032149 [PubMed - indexed for MEDLINE] Free PMC Article

Validation of gene expression profiles from cholestatic hepatotoxicants in vitro against human in vivo cholestasis.

Toxicol In Vitro. 2017 Oct;44:322-329. doi: 10.1016/j.tiv.2017.07.024. Epub 2017 Aug 1. PMID: 28778767 [PubMed - indexed for MEDLINE] Free Article

A model-based assay design to reproduce in vivo patterns of acute drug-induced toxicity.

Arch Toxicol. 2018 Jan;92(1):553-555. doi: 10.1007/s00204-017-2041-7. Epub 2017 Aug 29. No abstract available. PMID: 28852801 [PubMed - in process] Free PMC Article

Integrated 'omics analysis reveals new drug-induced mitochondrial perturbations in human hepatocytes.

Toxicol Lett. 2018 Jun 1;289:1-13. doi: 10.1016/j.toxlet.2018.02.026. Epub 2018 Mar 6. PMID: 29501571 [PubMed - indexed for MEDLINE]

SOX10 Single Transcription Factor-Based Fast and Efficient Generation of Oligodendrocytes from Human Pluripotent Stem Cells.

Stem Cell Reports. 2018 Feb 13;10(2):655-672. doi: 10.1016/j.stemcr.2017.12.014. Epub 2018 Jan 11. PMID: 29337119 [PubMed - in process] Free PMC Article

Efficient Recombinase-Mediated Cassette Exchange in hPSCs to Study the Hepatocyte Lineage Reveals AAVS1 Locus-Mediated Transgene Inhibition.

Ordovás L, Boon R, Pistoni M, Chen Y, Wolfs E, Guo W, Sambathkumar R, Bobis-Wozowicz S, Helsen N, Vanhove J, Berckmans P, Cai Q, Vanuytsel K, Eggermont K, Vanslembrouck V, Schmidt BZ, Raitano S, Van Den Bosch L, Nahmias Y, Cathomen T, Struys T, Verfaillie

Strategies for In Vivo Genome Editing in Nondividing Cells.

Trends Biotechnol. 2018 Apr 21. pii: S0167-7799(18)30088-X. doi: 10.1016/j.tibtech.2018.03.004. [Epub ahead of print] Review. PMID: 29685818 [PubMed - as supplied by publisher]

Generation of hepatocyte- and endocrine pancreatic-like cells from human induced endodermal progenitor cells.

PLoS One. 2018 May 11;13(5):e0197046. doi: 10.1371/journal.pone.0197046. eCollection 2018. PMID: 29750821 [PubMed - in process] Free PMC Article

Prediction of liver toxicity and mode of action using metabolomics in vitro in HepG2 cells.

Arch Toxicol. 2018 Feb;92(2):893-906. doi: 10.1007/s00204-017-2079-6. Epub 2017 Sep 30. PMID: 28965233 [PubMed - in process] Free PMC Article

Framework for the quality assurance of 'omics technologies considering GLP requirements.

Regul Toxicol Pharmacol. 2017 Dec;91 Suppl 1:S27-S35. doi: 10.1016/j.yrtph.2017.10.007. Epub 2017 Oct 5. PMID: 28987912 [PubMed - in process] Free Article

Legacy data sharing to improve drug safety assessment: the eTOX project.

Nat Rev Drug Discov. 2017 Dec;16(12):811-812. doi: 10.1038/nrd.2017.177. Epub 2017 Oct 13. PMID: 29026211 [PubMed - indexed for MEDLINE]

New microRNA Biomarkers for Drug-Induced Steatosis and Their Potential to Predict the Contribution of Drugs to Non-alcoholic Fatty Liver Disease.

López-Riera M, Conde I, Tolosa L, Zaragoza Á, Castell JV, Gómez-Lechón MJ, Jover R. Front Pharmacol. 2017 Jan 25;8:3. doi: 10.3389/fphar.2017.00003. eCollection 2017. PMID: 28179883 [PubMed] Free PMC Article

Customised in vitro model to detect human metabolism-dependent idiosyncratic drug-induced liver injury.

Arch Toxicol. 2018 Jan;92(1):383-399. doi: 10.1007/s00204-017-2036-4. Epub 2017 Jul 31. PMID: 28762043

Predicting drug-induced cholestasis: preclinical models.

Expert Opin Drug Metab Toxicol. 2018 Jun 11. doi: 10.1080/17425255.2018.1487399. [Epub ahead of print] PMID: 29888962 [PubMed - as supplied by publisher]

The application of new HARD-descriptor available from the CORAL software to building up NOAEL models.

Food Chem Toxicol. 2018 Feb;112:544-550. doi: 10.1016/j.fct.2017.03.060. Epub 2017 Mar 30. PMID: 28366846

Exposure to PFOA and PFOS and fetal growth: a critical merging of toxicological and epidemiological data.

Negri E, Metruccio F, Guercio V, Tosti L, Benfenati E, Bonzi R, La Vecchia C, Moretto A. Crit Rev Toxicol. 2017 Jul;47(6):482-508. doi: 10.1080/10408444.2016.1271972. Epub 2017 Feb 15. Review. PMID: 28617200 [PubMed - indexed for MEDLINE]

SAR for gastro-intestinal absorption and blood-brain barrier permeation of pesticides.

Chem Biol Interact. 2018 Jun 25;290:1-5. doi: 10.1016/j.cbi.2018.04.030. Epub 2018 May 16. PMID: 29753609

QSARpy: A new flexible algorithm to generate QSAR models based on dissimilarities. The log Kow case study.

Sci Total Environ. 2018 Oct 1;637-638:1158-1165. doi: 10.1016/j.scitotenv.2018.05.072. Epub 2018 May 14. PMID: 29801209

Adverse outcome pathways: a concise introduction for toxicologists.

Arch Toxicol. 2017 Nov;91(11):3697-3707. doi: 10.1007/s00204-017-2020-z. Epub 2017 Jun 28. PMID: 28660287

A frequent misinterpretation in current research on liver fibrosis: the vessel in the center of CCl<sub>4</sub>-induced pseudolobules is a portal vein.

Arch Toxicol. 2017 Nov;91(11):3689-3692. doi: 10.1007/s00204-017-2040-8. Epub 2017 Aug 19. PMID: 28825120

Comprehensive Landscape of Nrf2 and p53 Pathway Activation Dynamics by Oxidative Stress and DNA Damage.

Chem Res Toxicol. 2017 Apr 17;30(4):923-933. doi: 10.1021/acs.chemrestox.6b00322. Epub 2016 Dec 16. PMID: 27982581 [PubMed - indexed for MEDLINE]

Highlight report: 'Big data in the 3R's: outlook and recommendations', a roundtable summary.

Arch Toxicol. 2018 Feb;92(2):1015-1020. doi: 10.1007/s00204-017-2145-0. Epub 2018 Jan 16. No abstract available. PMID: 29340744

Dynamic imaging of adaptive stress response pathway activation for prediction of drug induced liver injury.

Arch Toxicol. 2018 May;92(5):1797-1814. doi: 10.1007/s00204-018-2178-z. Epub 2018 Mar 3. PMID: 29502165

Ab initio chemical safety assessment: A workflow based on exposure considerations and non-animal methods.

Comput Toxicol. 2017 Nov;4:31-44. doi: 10.1016/j.comtox.2017.10.001. PMID: 29214231 [PubMed] Free PMC Article

Towards optimisation of induced pluripotent cell culture: Extracellular acidification results in growth arrest of iPSC prior to nutrient exhaustion.

Toxicol In Vitro. 2017 Dec;45(Pt 3):445-454. doi: 10.1016/j.tiv.2017.07.023. Epub 2017 Aug 15. PMID: 28821352 [PubMed - in process]

A snapshot on the progress of in vitro toxicology for safety assessment.

Toxicol In Vitro. 2017 Dec;45(Pt 3):269-271. doi: 10.1016/j.tiv.2017.10.024. No abstract available. PMID: 29195642 [PubMed - in process]

Toxicol. Res., 2018, DOI: 10.1039/C8TX00051D

Received: March 23, 2018; doi:10.14573/altex.1803231; ALTEX 35(2), 2018

January 21, 2018; doi:10.14573/altex.1712182; ALTEX 35(2), 2018

April 5, 2018; doi:10.14573/altex.180

Recommendation on test readiness criteria for new approach methods in toxicology: Exemplified for developmental neurotoxicity

ALTEX. 2018 Feb 23. doi: 10.14573/altex.1712081. [Epub ahead of print]

Consensus statement on the need for innovation, transition and implementation of developmental neurotoxicity (DNT) testing for regulatory purposes

Toxicol Appl Pharmacol. 2018 Feb 12. pii: S0041-008X(18)30043-7. doi: 10.1016/j.taap.2018.02.004. [Epub ahead of print]

A high-throughput approach to identify specific neurotoxicants/ developmental toxicants in human neuronal cell function assays

ALTEX. 2018 Jan 21. doi: 10.14573/altex.1712182. [Epub ahead of print]

Stage-specific metabolic features of differentiating neurons: Implications for toxicant sensitivity

Toxicol Appl Pharmacol. 2017 Dec 24. pii: S0041-008X(17)30494-5. doi: 10.1016/j.taap.2017.12.013. [Epub ahead of print]

An adverse outcome pathway for parkinsonian motor deficits associated with mitochondrial complex I inhibition

Arch Toxicol. 2018 Jan;92(1):41-82. doi: 10.1007/s00204-017-2133-4. Epub 2017 Dec 5. Review.

A structure-activity relationship linking non-planar PCBs to functional deficits of neural crest cells: new roles for connexins

Arch Toxicol. 2017 Nov 21. doi: 10.1007/s00204-017-2125-4. [Epub ahead of print]

New animal-free concepts and test methods for developmental toxicity and peripheral neurotoxicity

Altern Lab Anim. 2017 Nov;45(5):253-260.

Adverse outcome pathways: opportunities, limitations and open questions

Arch Toxicol. 2017 Nov;91(11):3477-3505. doi: 10.1007/s00204-017-2045-3. Epub 2017 Oct 19.

Combination of multiple neural crest migration assays to identify environmental toxicants from a proof-of-concept chemical library

Arch Toxicol. 2017 Nov;91(11):3613-3632. doi: 10.1007/s00204-017-1977-y. Epub 2017 May 5.

Tipping Points and Endogenous Determinants of Nigrostriatal Degeneration by MPTP

Trends Pharmacol Sci. 2017 Jun;38(6):541-555. doi: 10.1016/ Epub 2017 Apr 23. Review.

OECD/EFSA workshop on developmental neurotoxicity (DNT): The use of non-animal test methods for regulatory purposes

ALTEX. 2017;34(2):311-315. doi: 10.14573/altex.1701171. No abstract available.

Impairment of human neural crest cell migration by prolonged exposure to interferon-beta

Arch Toxicol. 2017 Oct;91(10):3385-3402. doi: 10.1007/s00204-017-1966-1. Epub 2017 Apr 1.

Stem Cell Transcriptome Responses and Corresponding Biomarkers That Indicate the Transition from Adaptive Responses to Cytotoxicity

Chem Res Toxicol. 2017 Apr 17;30(4):905-922. doi: 10.1021/acs.chemrestox.6b00259. Epub 2016 Dec 21.

Hybrid optimal descriptors as a tool to predict skin sensitization in accordance to OECD principles

Toxicology Letters 275 (2017) 57–66

The index of ideality of correlation: A criterion of predictability of QSAR models for skin permeability?

Science of the Total Environment 586 (2017) 466–472

The application of new HARD-descriptor available from the CORAL software to building up NOAEL models

Food and Chemical Toxicology xxx (2017) 1-7

The index of ideality of correlation: A criterion of predictive potential of QSPR/QSAR models?

Mutat Res Gen Tox En 819 (2017) 31–37

CORAL: Binary classifications (active/inactive) for drug-induced liver injury

Toxicology Letters 268 (2017) 51–57

Human environmental disease network: A computational model to assess toxicology of contaminants

Altex, published October 21, 2016

In Silico Systems Pharmacology to Assess Drug's Therapeutic and Toxic Effects

Current Pharmaceutical Design, Volume 22, Number 46, December 2016, pp. 6895-6902(8) - DOI: 10.2174/1381612822666160907093215

​The ascending pathophysiology of cholestatic liver disease

Hepatology. 2017 Feb;65(2):722-738

In vitro acute and developmental neurotoxicity screening: an overview of cellular platforms and high-throughput technical possibilities

January 2017 - Arch Toxicol - DOI: 10.1007/s00204-016-1805-9

Improved building up a model of toxicity towards Pimephales promelas by the Monte Carlo method

November 2016 - Environmental Toxicology and Pharmacology 48 (2016) 278–285

A Multi-Compartment Liver Model for the Prediction of Toxicokinetics

September 2016 - Toxicology Letters 258S (2016) S62–S324

Unraveling cellular pathways contributing to drug-induced liver injury by dynamical modeling

Expert Opin Drug Metab Toxicol. 2016 Sep 23:1-13 - DOI:10.1080/17425255.2017.1234607

September 2016 - Front. Cell. Neurosci. 10:215. doi:10.3389/fncel.2016.00215

Good Cell Culture Practice for Stem Cells and Stem-Cell-Derived Models

August 2016 - ALTEX 34(1), 2017 - 10.14573/altex.1607121

Reference compounds for alternative test methods to indicate developmental neurotoxicity (DNT) potential of chemicals: example lists and criteria for their selection and use

July 2016 - DOI: 10.14573/altex.1604201

May 2016 - Arch Toxicol - DOI 10.1007/s00204-016-1741-8

March 2016 - Arch Toxicol - DOI 10.1007/s00204-016-1698-7

ALTEX 33(2), 2016