With thanks to Hennicke Kamp (BASF), Susanne Hougaard (National Food Institute -DTU), Bob van de Water (LACDR, University of Leiden) , Martijn J. Moné (LACDR, University of Leiden), Bart van der Burg (BDS), Barry Hardy (Douglas Connect), Rabea Gräpel (LACDR, University of Leiden), Si S. Wang and Richard Currie (Syngenta) for their valuable contribution, as well as to Michael Hughes (Center for Alternatives to Animal Testing) for the graphic design and layout.