Case Studies

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Prediction of microvesicular liver steatosis – a read-across case study with short branched carboxylic acids

REACH, read-across, RDT, systemic toxicity, NAM, uncertainty, mode of action

OECD IATA Case Study Report available.

Prediction of developmental and reproductive toxicity (DART): a read-across case study with short branched carboxylic acids

REACH, read-across, DART

OECD IATA Case Study Report available.

Peroxisome proliferation / Organic anion transporter interference

REACH, read-across, RDT, systemic toxicity, NAM, metabolomics

Repeated dose toxicity (RDT)/ Developmental and reproductive toxicity (DART) – Mitochondrial toxicity. The case of the strobilurin fungicides.

REACH, read-across, RDT, DART, NAM, AOP

Repeated dose toxicity (RDT)/ Developmental and reproductive toxicity (DART) – Mitochondrial toxicity. The case of mitochondrial complex I inhibitors: deguelin and rotenone.

REACH, read-across, RDT, DART, NAM, AOP

Liver toxicity

RDT, liver toxicity, NAM

Popcorn lung – a read-across case study on diketones class group

Read-across, RDT, REACH, respiratory disease, NAM

Parabens

Cosmetics regulation, industry-sponsored case study, read-across, ab-initio

OECD IATA Case Study Report available.

Multi-target organ toxicity

REACH, RDT, LOEL

High-concern toxicity profile screening

RDT/DART ab initio

Next-generation risk assessment of developmental neurotoxicity liabilities of neonicotinoid insecticides

DART, OECD DNT TG426, IATA

Multi-organ metabolism (MOM)

REACH, RTD, hepatotoxicity, nephrotoxicity, metabolism, kinetics